Reproducible automated breast density measure with no ionizing radiation using fat-water decomposition MRI
| Autor: | Jie, Ding, Alison T, Stopeck, Yi, Gao, Marilyn T, Marron, Betsy C, Wertheim, Maria I, Altbach, Jean-Philippe, Galons, Denise J, Roe, Fang, Wang, Gertraud, Maskarinec, Cynthia A, Thomson, Patricia A, Thompson, Chuan, Huang |
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| Rok vydání: | 2017 |
| Předmět: |
Reproducibility of Results
Water Breast Neoplasms Magnetic Resonance Imaging Article Pattern Recognition Automated Tamoxifen Adipose Tissue Risk Factors Radiation Ionizing Image Processing Computer-Assisted Humans Female Breast skin and connective tissue diseases Breast Density Mammography Retrospective Studies |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 48(4) |
| ISSN: | 1522-2586 |
| Popis: | BACKGROUND: Increased breast density is a significant independent risk factor for breast cancer, and recent studies show that this risk is modifiable. Hence, breast density measures sensitive to small changes are desired. PURPOSE: Utilizing fat-water decomposition MRI, we propose an automated, reproducible breast density measurement, which is non-ionizing and directly comparable to mammographic density (MD). STUDY TYPE: Retrospective study. POPULATION: The study included two sample sets of breast cancer patients enrolled in a clinical trial, for concordance analysis with MD (40 patients) and reproducibility analysis (10 patients). FIELD STRENGTH/SEQUENCE: The majority of MRI scans (59 scans) were performed on a 1.5T GE Signa scanner using radial IDEAL-GRASE sequence, while the remaining (7 scans) were performed on a 3T Siemens Skyra using 3D Cartesian 6-echo GRE sequence with a similar fat-water separation technique. ASSESSMENT: After automated breast segmentation, breast density was calculated using FraGW, a new measure developed to reliably reflect the amount of fibroglandular tissue and total water content in the entire breast. Based on its concordance with MD, FraGW was calibrated to MR-based breast density (MRD) to be comparable to MD. A previous breast density measurement, Fra80—the ratio of breast voxels with |
| Databáze: | OpenAIRE |
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