| Autor: |
Laura, Kiscsatári, Márta, Sárközy, Bence, Kővári, Zoltán, Varga, Kamilla, Gömöri, Nikolett, Morvay, István, Leprán, Hargita, Hegyesi, Gabriella, Fábián, Bálint, Cserni, Gábor, Cserni, Tamás, Csont, Zsuzsanna, Kahán |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
In vivo (Athens, Greece). 30(5) |
| ISSN: |
1791-7549 |
| Popis: |
Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed.Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested.Signs and symptoms of RIHD occurred12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks.The studied parameters could be used in future experiments for testing protective agents for prevention of radiation heart injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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