Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy

Autor: Huan Bin, Wang, Han, Yao, Chu Shu, Li, Lun Xi, Liang, Yao, Zhang, Ying Xuan, Chen, Jing-Yuan, Fang, Jie, Xu
Rok vydání: 2017
Předmět:
Zdroj: Journal of digestive diseases. 18(10)
ISSN: 1751-2980
Popis: Programmed death-ligand 1 (PD-L1) expression in colorectal cancer (CRC) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy. However, therapeutic response has also been found in patients without PD-L1 expression in the primary tumor. In the present study, we aimed to clarify the prevalence of PD-L1 in primary and metastatic CRC.The expression of PD-L1 was determined by immunohistochemistry in matched primary and metastatic CRC.PD-L1 expression was significantly more prevalent in metastatic CRCs than in primary tumors, and the expression of PD-L1 in primary CRC may not represent the tumors that spread to distant organs. Positive expression of PD-L1 was found in 81.8% of metastatic CRC, being significantly more prevalent than in primary CRC (40.9%; P = 0.012, Fisher's exact test). While comparing the primary and metastatic lesions of the same patients, we found that PD-L1 expression frequently increased during the metastatic process. However, PD-L1 expression was rarely decreased in metastatic lesions. Intratumoral heterogeneity expression of PD-L1 was found in both metastatic CRC (22.2%) and primary CRCs (33.3%). PD-L1 was prevalently expressed in metastatic CRC, and increased PD-L1 expression was frequently found in metastatic CRC as compared to primary tumors.PD-L1 expression in metastatic CRC should be considered as an independent factor while evaluating the suitability of patients for immunotherapy.
Databáze: OpenAIRE
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