Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors

Autor:	V J, Poirier, A E, Hershey, K E, Burgess, B, Phillips, M M, Turek, L J, Forrest, L, Beaver, D M, Vail
Rok vydání:	2004
Předmět:	Diarrhea Male Osteosarcoma Neutropenia Paclitaxel Vomiting Incidence Records Mammary Neoplasms Animal Antineoplastic Agents Phytogenic Survival Analysis Thrombocytopenia Drug Administration Schedule Dogs Wisconsin Animals Female Dog Diseases Infusions Intravenous Retrospective Studies
Zdroj:	Journal of veterinary internal medicine. 18(2)
ISSN:	0891-6640
Popis:	Paclitaxel (Taxol) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m2 i.v. over 3-6 hours every 3 weeks. Dogs received premedication with antihistimines and corticosteroids to reduce hypersensitivity reactions. However, 64% of the dogs still experienced allergic reactions. Six dogs (24%) had grade 3 or 4 neutropenia, 6 dogs (24%) required hospitalization and 3 dogs (12%) died of sepsis. Five dogs (20%) had a partial response (osteosarcoma [2 dogs] mammary carcinoma [2 dogs] and malignant histiocytosis [1 dog]) for a median duration of 53 days. The overall toxicity was unacceptable at the 165 mg/m2 dose. Therefore, subsequent evaluations of paclitaxel in tumor-bearing dogs should a starting dose of 132 mg/m2 i.v. every 3 weeks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0c24958d829b48d48f24071db9322e49 https://pubmed.ncbi.nlm.nih.gov/15058774 Zobrazit plný text záznamu Plný text