[Composition and immunological activity of membrane-bound surface glycoprotein from Crithidia oncopelti]

Autor:	N N, Sukhareva, M Sh, Zaretskaia, V A, Khorokhorina, N S, Egorov, M M, Viadro, T S, Titova, I P, Fomina
Rok vydání:	1989
Předmět:	Leukemia Experimental Membrane Glycoproteins Leukemia P388 Macrophages Monosaccharides In Vitro Techniques Mice Adjuvants Immunologic Crithidia Animals Ascitic Fluid Lymphocytes Amino Acids Spleen Stearic Acids
Zdroj:	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 34(11)
ISSN:	0235-2990
Popis:	A membrane-bound glycoprotein with a molecular weight of 10000-12000 was isolated from Crithidia oncopelti and purified. The glycoprotein contained peptide, carbohydrate and lipid fragments and phosphorus. The peptide fragment was represented by 10 amino acids. The carbohydrate fragment was represented by 7 monosaccharides. The lipid part was mainly represented by stearic acid. The glycoprotein showed immunostimulating properties. It had a comitogenic effect on murine spleen cells in vitro and induced tumoricidal activity in murine peritoneal macrophages in vitro and in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0c00b8a22a773104705d05b647376d90 https://pubmed.ncbi.nlm.nih.gov/2633698 Zobrazit plný text záznamu