Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease

Autor:	C D, Smith, R J, Kryscio, F A, Schmitt, M A, Lovell, L X, Blonder, W S, Rayens, A H, Andersen
Rok vydání:	2005
Předmět:	Cerebral Cortex Cognition Time Factors Alzheimer Disease Echo-Planar Imaging Brain Humans Female Middle Aged Magnetic Resonance Imaging Risk Assessment
Zdroj:	Journal of neuroimaging : official journal of the American Society of Neuroimaging. 15(3)
ISSN:	1051-2284
Popis:	The authors sought to determine whether known alterations of brain function in normal individuals who are at high risk for Alzheimer's disease (AD) worsen or stay the same after a significant interval of time.The authors used functional magnetic resonance imaging (fMRI) to observe cortical activation during confrontation naming in 14 women with high AD risk and 10 with low risk, based on family history and apolipoprotein-E4 allele status. They repeated the identical scan protocol in the same patients after 4 years.fMRI activation in high-AD-risk participants was found to be further diverged from that of their low-AD-risk counterparts over this period.fMRI may report on the presence and progression of neuropathology in the ventral temporal cortex or in functionally connected regions in presymptomatic AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0be44e33634446b72393907019dd1138 https://pubmed.ncbi.nlm.nih.gov/15951411 Zobrazit plný text záznamu Plný text