Combined Small and Squamous Transformation in EGFR-mutated Lung Adenocarcinoma
| Autor: | Taiki, Hakozaki, Miyako, Kitazono, Mikio, Takamori, Takahiro, Kiriu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lung Neoplasms
Biopsy acquired resistance Adenocarcinoma of Lung Case Report Small Cell Lung Carcinoma respiratory tract diseases ErbB Receptors non-small-cell lung cancer Drug Resistance Neoplasm Antineoplastic Combined Chemotherapy Protocols Mutation Carcinoma Squamous Cell Humans histologic transformation Female Carcinoma Small Cell EGFR mutation Protein Kinase Inhibitors Aged Neoplasm Staging |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Histologic transformation has been described as an acquired mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We herein report the case of a woman with stage IV lung adenocarcinoma harboring EGFR exon 19 deletions who was initially treated with EGFR-TKIs; several cytotoxic chemotherapeutic regimens were used when resistance developed. A lymph node re-biopsy revealed histologic transformation of the tumor to combined small-cell lung cancer and squamous cell carcinoma with retained EGFR exon 19 deletions. Following sequential chemotherapy appropriate for transformed histology, a clinical response was achieved. |
| Databáze: | OpenAIRE |
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