| Autor: |
Zhi Hao, Kwok, Bin, Zhang, Xiao Hong, Chew, Jia Jia, Chan, Velda, Teh, Henry, Yang, Dennis, Kappei, Yvonne, Tay |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Cancer research. 81(5) |
| ISSN: |
1538-7445 |
| Popis: |
Approximately half of all miRNA reside within intronic regions and are often cotranscribed with their host genes. However, most studies of intronic miRNA focus on individual miRNA, while conversely most studies of protein-coding and noncoding genes frequently ignore any intron-derived miRNA. We hypothesize that the individual components of such multigenic loci may play cooperative or competing roles in driving disease progression and that examining the combinatorial effect of these components would uncover deeper insights into their functional importance. To address this, we performed systematic analyses of intronic miRNA:host loci in colon cancer. The |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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