Novel HLA allele, HLA-B*4013, identified from a potential bone marrow recipient. Putative gene conversion events with donor sequence

Autor:	P V, Blanco, G, Theile, C, Marcos, M, Capucchio, N, Lindel, L, Sala, L, Fainboim, M L, Satz
Rok vydání:	2001
Předmět:	Male Base Sequence HLA-B40 Antigen Molecular Sequence Data Gene Conversion Tissue Donors HLA-B Antigens Leukemia Myelogenous Chronic BCR-ABL Positive Humans Female Amino Acid Sequence Child Alleles Bone Marrow Transplantation
Zdroj:	Tissue antigens. 57(4)
ISSN:	0001-2815
Popis:	A new B40 allele was identified in a leukemic Caucasian patient. This allele, designated B*4013, differs in alpha 1 domain from B*4002 at six amino acidic positions: 67, 77, 80, 81, 82 and 83. Most of this substitutions could alter the antigen binding site of the HLA-B molecule. B*4013 may have originated by gene conversion or reciprocal recombination involving B*4002 as the recipient allele of sequence donated by B*4406. The new allele was serologically typed as a "blank" associated with the Bw4 epitope.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0b121a3de17a1ab12164bb16cd291560 https://pubmed.ncbi.nlm.nih.gov/11380953 Zobrazit plný text záznamu Plný text ve formátu PDF