Intrajejunal vs oral levodopa-carbidopa therapy in Parkinson disease

Autor:	Popa, Luminita C., Leucuta, Daniel-Corneliu, Tohanean, Nicoleta, Popa, Stefan-Lucian, Perju-Dumbrava, Lacramioara
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Aged 80 and over Male Romania Observational Study Administration Oral Carbidopa Parkinson Disease LCIG Middle Aged nervous system diseases Injections Cohort Studies Levodopa Drug Combinations Jejunum PD Humans Female Research Article levodopa-carbidopa intestional gel Aged Retrospective Studies
Zdroj:	Medicine
ISSN:	1536-5964 0025-7974
Popis:	Levodopa-carbidopa intestinal gel (LCIG) is a method of continuous administration of levodopa – the standard treatment in Parkinson disease (PD, a neurodegenerative disorder characterized by resting tremor, rigidity, gait impairment, and bradykinesia), thought to reduce the short-life and pulsatile problems of oral administration. We aimed to study the effects of Levodopa-Carbidopa therapy in 2 separate groups: one with intrajejunal administration of Levodopa-Carbidopa gel and the second with oral therapy. We performed an observational retrospective Romanian cohort study on 61 patients diagnosed with PD patients, with Hoehn and Jahr 3 and 4 stages, recruited from a single regional tertiary center in Cluj-Napoca, Romania, between 2009 and 2019. The mean adjusted UPDRS III (and similarly for UPDRS II) improved in the LCIG compared to the oral therapy group with 15.6 (95% CI 12.0–19.2, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::08e485481b80807ae00d4bdba4be3d50 http://europepmc.org/articles/PMC7668461 Zobrazit plný text záznamu