| Autor: |
L, Feller, M H, Motswaledi, R, Chandran, U M E, Chikte, R, Meyerov, J, Lemmer |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging. 66(5) |
| ISSN: |
1029-4864 |
| Popis: |
Lupus erythematosus is a chronic autoimmune inflammatory disease with diverse clinical manifestations including arthritis, skin disorders and kidney disease. Pathologically it is characterised by complex interactions between multiple genetic, epigenetic and extraneous factors; and serologically by the presence of a variety of antibodies which are reactive to intracellular molecular constituents. Impaired clearance of apoptotic cells and of immune complexes, loss of immune tolerance to self-antigens and dysregulation of the cytokine network act synergistically with extraneous factors such as ultraviolet radiation, viruses and certain drugs to induce and sustain lupus erythematosus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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