Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway
| Autor: | P J, Turner, J R, Maggs, J C, Foreman |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Cross-Over Studies omega-N-Methylarginine Receptor Bradykinin B2 Anti-Inflammatory Agents Non-Steroidal respiratory system Middle Aged Bradykinin Nitric Oxide NG-Nitroarginine Methyl Ester Double-Blind Method Papers otorhinolaryngologic diseases Humans Drug Interactions Bronchial Hyperreactivity Enzyme Inhibitors Nitric Oxide Synthase Platelet Activating Factor Bradykinin Receptor Antagonists |
| Zdroj: | British journal of pharmacology. 131(2) |
| ISSN: | 0007-1188 |
| Popis: | 1. The effects of inhibitors of nitric oxide synthase (NOS) on the responsiveness of the human nasal airway were investigated, by measuring the nasal response to histamine and bradykinin. 2. Repeated intranasal administration of N(G)-nitro-L-arginine methyl ester (L-NAME) or N(G)-monomethyl-L-arginine (L-NMMA), 1 micromol per nostril every 30 min for 6 h, increased the nasal obstruction induced by histamine, 50 - 500 microg, and bradykinin, 200 microg per nostril. A single administration of L-NAME, 1 micromol per nostril did not induce hyperresponsiveness to histamine. 3. Pretreatment with L-arginine, 30 micromol, abolished the hyperresponsiveness to histamine caused by L-NAME, 1 micromol. Pretreatment with N(G)-nitro-D-arginine methyl ester (D-NAME), 1 micromol, did not induce hyperresponsiveness to histamine. 4. Repeated administration of L-NAME, 1 micromol, caused a significant reduction in the amount of nitric oxide measured in the nasal cavity. 5. Neither L-NMMA, 1 micromol, nor L-arginine, 30 micromol, altered the nasal hyperresponsiveness induced by platelet activating factor (PAF), 60 microg. PAF did not alter the levels of nitric oxide in the nasal cavity. 6. The results suggest that inhibition of nitric oxide synthase induces a hyperresponsiveness in the human nasal airway, and that this occurs by a mechanism different from that involved in PAF-induced hyperresponsiveness. |
| Databáze: | OpenAIRE |
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