MSCs ameliorates DPN induced cellular pathology via [Ca
| Autor: | Harish C, Chandramoorthy, Ismaeel, Bin-Jaliah, Hussian, Karari, Prasanna, Rajagopalan, Mohammed Eajaz, Ahmed Shariff, Ahmed, Al-Hakami, Suliman M, Al-Humayad, Fawzi A, Baptain, Humeda Suekit, Ahmed, Hanaa Z, Yassin, Mohamed A, Haidara |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male Time Factors Neural Conduction Action Potentials Apoptosis Mesenchymal Stem Cell Transplantation Diabetes Mellitus Experimental Diabetic Neuropathies Reaction Time Animals Homeostasis Humans Peripheral Nerves Rats Wistar Cells Cultured Neurons Mesenchymal Stem Cells Coculture Techniques Oxidative Stress Diabetes Mellitus Type 2 Cytokines Calcium Cord Blood Stem Cell Transplantation Inflammation Mediators Apoptosis Regulatory Proteins Signal Transduction |
| Zdroj: | Journal of cellular physiology. 233(2) |
| ISSN: | 1097-4652 |
| Popis: | The MSCs of various origins are known to ameliorate or modulate cell survival strategies. We investigated, whether UCB MSCs could improve the survival of the human neuronal cells and/or fibroblast assaulted with DPN sera. The results showed, the co-culture of UCB MSCs with human neuronal cells and/or fibroblasts could effectively scavenge the pro-inflammatory cytokines TNF-α, IL-1β, IFN-ɤ and IL - 12 and control the pro-apoptotic expression of p53/Bax. Further co-culture of UCB MSCs have shown to induce anti-inflammatory cytokines like IL-4, IL-10 and TGF-β and anti-apoptotic Bclxl/Bcl2 expression in the DPN sera stressed cells. Amelioration of elevated [Ca |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text