| Autor: |
Pirkko, Kellokumpu-Lehtinen, Tuija, Tuunanen, Raija, Asola, Liisa, Elomaa, Mirja, Heikkinen, Riitta, Kokko, Ritva, Järvenpää, Ilari, Lehtinen, Abdel, Maiche, Jaana, Kaleva-Kerola, Mauri, Huusko, Kari, Möykkynen, Timo, Ala-Luhtala |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Anticancer research. 33(6) |
| ISSN: |
1791-7530 |
| Popis: |
Weekly paclitaxel is widely used in the treatment of metastatic breast cancer (MBC). Our aim was to test its efficacy and tolerability as a second-line therapy for MBC in daily oncology practice.Paclitaxel (90 mg/m(2)) was given intravenously three times weekly in a 4-week cycle to 91 patients with disease progression after hormonal (42%) or cytostatic therapy (57%). The median age was 54 years; metastatic sites were the lung (39%), liver (52%) and bone (47%). 64% of patients had more than one site of metastasis.Median time-to-progression was 7.5 months (range=6.5-8.5 months) and median overall survival time was 20.1 months (range=13.7-26.5 months). We observed 10 complete (12%) and 37 partial (43%) responses (an overall response rate of 55%). Severe side-effects were rare (grade 3-4 neutropenia 13% and septic episodes in three cases).Weekly paclitaxel was shown to be an effective and well-tolerated treatment for advanced breast cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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