Serum Contactin-1 in CIDP
| Autor: | Wieske, Luuk, Martín-Aguilar, Lorena, Fehmi, Janev, Lleixà, Cinta, Koel-Simmelink, Marleen J.A., Chatterjee, Madhurima, van Lierop, Zoë, Killestein, Joep, Verhamme, Camiel, Querol, Luis, Rinaldi, Simon, Teunissen, Charlotte E., Eftimov, Filip |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Neurology® Neuroimmunology & Neuroinflammation article-version (Version of Record) 3 |
| ISSN: | 2332-7812 |
| Popis: | Objective To investigate whether serum levels of contactin-1, a paranodal protein, correlate with paranodal injury as seen in patients with CIDP with antibodies targeting the paranodal region. Methods Serum contactin-1 levels were measured in 187 patients with CIDP and 222 healthy controls. Paranodal antibodies were investigated in all patients. Results Serum contactin-1 levels were lower in patients (N = 41) with paranodal antibodies compared with patients (N = 146) without paranodal antibodies (p < 0.01) and showed good discrimination between these groups (area under the curve 0.84; 95% CI: 0.76–0.93). Conclusions These findings suggest that serum contactin-1 levels have the potential to serve as a possible diagnostic biomarker of paranodal injury in CIDP. Classification of Evidence This study provides class II evidence that serum contactin-1 levels can discriminate between patients with CIDP with or without paranodal antibodies with a sensitivity of 71% (95% CI: 56%–85%) and a specificity of 97% (95% CI: 83%–100%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|