Serum lactate is a useful predictor of death in severe sepsis in patients with pemphigus vulgaris

Autor: Andrés, Tirado-Sánchez, Denisse, Vázquez-González, Rosa María, Ponce-Olivera, Griselda, Montes de Oca-Sánchez
Rok vydání: 2012
Předmět:
Zdroj: Acta dermatovenerologica Alpina, Pannonica, et Adriatica. 21(1)
ISSN: 1581-2979
Popis: Serum lactate is a useful prognostic marker in severe sepsis; high levels of serum lactate in critically ill patients are related to high mortality risk; assessing serum lactate levels in patients with pemphigus vulgaris is justified. The objective was to determine the role of serum lactate as a predictor of shock and its outcome in patients with pemphigus vulgaris and severe sepsis without acute organ dysfunction.Thirty-seven patients with pemphigus vulgaris, 22 with severe sepsis and 15 without sepsis. Blood lactate levels were analyzed. The outcome was recorded as survival or non-survival.High serum lactate levels, compared with intermediate and low levels, were significantly associated with increased 28-day mortality in patients with severe sepsis. The 28-day mortality for the cohort was 27.3%.Initial serum lactate was associated with mortality in pemphigus vulgaris with severe sepsis. Patients with severe sepsis and with high serum lactate levels (≥ 4 mmol/L) constitute a potential risk group that may benefit from more aggressive treatment.
Databáze: OpenAIRE