A case series of critically ill patients with anti- N-methyl-D-aspartate receptor encephalitis

Autor: Paul J, Young, Stuart, Baker, Elena, Cavazzoni, Simon J, Erickson, Anand, Krishnan, Peter S, Kruger, Alan H, Rashid, Brad A, Wibrow
Rok vydání: 2013
Předmět:
Zdroj: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. 15(1)
ISSN: 1441-2772
Popis: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis causes autonomic disturbances, behavioural changes and abnormal movements. It is often a paraneoplastic phenomenon that occurs in association with ovarian teratomas and is the most common paraneoplastic encephalitis. We report nine cases of critically ill patients with anti- NMDA receptor encephalitis from Australia and New Zealand. One patient died and one had a poor neurological recovery. The remaining patients made substantial or complete neurological recoveries. This case series highlights that patients with anti-NMDA receptor encephalitis: • often require long periods of support in an intensive care unit; • may develop tracheostomy complications related to hypersalivation; • may develop life-threatening hyperthermia; • can have ovarian teratomas despite normal investigations; and • often have very abnormal movements that are difficult to control and make ongoing care difficult.
Databáze: OpenAIRE