Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H

Autor: Cecília M S Q, Aranha, David, Reiner-Link, Luisa R, Leitzbach, Flavia B, Lopes, Holger, Stark, João Paulo S, Fernandes
Rok vydání: 2022
Zdroj: Bioorganicmedicinal chemistry. 78
ISSN: 1464-3391
Popis: Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a set of 21 substituted aryl-alkyl-piperazines were designed, prepared and tested for their binding affinities at histamine H
Databáze: OpenAIRE