[Expression and significance about VEGF, KDR, MMP-1, and transcription factor Ets-1 in human cervical carcinoma]
| Autor: | Feng-lian, Xu, Yu-lin, Li, Zhan-dong, Wang, You-ji, Feng |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A Neovascularization Pathologic Proto-Oncogene Proteins c-ets Uterine Cervical Neoplasms Middle Aged Protein-Tyrosine Kinases Proto-Oncogene Protein c-ets-1 Receptors Vascular Endothelial Growth Factor Proto-Oncogene Proteins Carcinoma Squamous Cell Humans Female Matrix Metalloproteinase 1 In Situ Hybridization Aged Transcription Factors |
| Zdroj: | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 25(4) |
| ISSN: | 1000-503X |
| Popis: | To study the expression of VEGF, KDR, MMP-1, and its transcription factor Ets-1 on the interstitial neovasculogenesis in human cervical carcinoma on molecular level, which may provide further theoretic bases on judgement of prognosis and explain interregularity between neovasculagenetic factors.VEGF, KDR, MMP-1, and Ets-1 were detected in 87 cervical carcinomas by in situ hybridization and immunohistochemistry. The survival curves for patients with detected tumors were compared with the curves for those without tumors. Multivariate analyses were performed with Pearson analysis.VEGF mRNA and its protein were mainly expressed in cytoplasms of tumor cells, positive rate was 78.6% (68/87) and 70.4% (61/87) respectively. KDR mRNA and its protein were mainly expressed in vascular endothelial cells, as correlation coefficient between KDR and VEGF was 0.892. Over expression of MMP-1 was seen in both endothelial cells and tumor cells, especially in hyperplasia of endothelial cells. Ets-1 was mainly expressed in both endothelial cells and tumor cells, correlation coefficient between Ets-1 and KDR, MMP-1, was 0.900 and 0.873, respectively. Four factors of above were highly related with tumor differentiation, lymph nodes metastasis as well as 5 years survival rate.VEGF, KDR, MMP-1, and Ets-1 are important factors on neovasculogenesis in cervical carcinoma, which may be considered to be reference indicator for determining biology behavior of cervical carcinoma, and may provide further theoretic bases on antineovasculagenetic therapy. |
| Databáze: | OpenAIRE |
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