| Autor: |
J, Lindsten, L, Marsk, K, Berglund, L, Iselius, N, Ryman, G, Annerén, B, Kjessler, F, Mitelman, I, Nordenson, J, Wahlström, L, Vejlens |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Human genetics. Supplement. 2 |
| ISSN: |
0172-7699 |
| Popis: |
The incidence of Down's syndrome has been studied among children born in Sweden during the years 1968-1977. The risk for mothers of different ages of bearing such a child did not change during these years. This does not exclude that a change in incidence might have occurred in smaller areas of the country but escaped detection for statistical reasons. A higher than expected number of children with Down's syndrome were born in a few communities, which most likely is a chance event. No correlation could be detected between the incidence of Down's syndrome and a number of socioeconomic variables. The correlation with maternal age was studied in detail. There was a significant excess of males among both the newborn children with Down's syndrome and fetuses with trisomy 21 aborted after prenatal diagnosis. A similar tendency was found among the cases with a chromosome mosaicism but not among those with a translocation. Two hypotheses are put forward to explain the excess of males with trisomy 21. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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