The management of myxofibrosarcoma - a ten-year experience in a single specialist centre
| Autor: | J, Daniels, C M, Green, A, Freemont, A, Paul |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Aged 80 and over Male Extremities Histiocytoma Malignant Fibrous Middle Aged Limb Salvage Myxosarcoma Prognosis Disease-Free Survival Tumor Burden Cohort Studies Tertiary Care Centers Young Adult Humans Female Orthopedic Procedures Radiotherapy Adjuvant Neoplasm Metastasis Neoplasm Recurrence Local Aged Neoplasm Staging Retrospective Studies |
| Zdroj: | Acta orthopaedica Belgica. 80(3) |
| ISSN: | 0001-6462 |
| Popis: | The aim of this study was to assess the management of myxofibrosarcoma in a single specialist centre, and examine factors contributing to local recurrence, metastasis and patient survival. Retrospective analysis of the referral, diagnosis, and management were obtained. Outcome measures including local recurrence, metastasis and death were recorded. 30 patients (mean age of 65.8 years) were treated for myxofibrosarcoma with limb salvage surgery between January 2003 and July 2012. 25 patients were treated for primary disease. Mean follow-up was 49 months (range 10-122). Larger tumours were most likely to metastasise (p = 0.041). Tumour size, resection margin and grade did not predict local recurrence or death. Local recurrence developed in eight patients (26.7%) with six subsequently requiring amputation, and four patients (16.7%) developed metastasis. Our results regarding local control and patient survival compare with that of the literature regarding limb salvage for primary disease, but amputation may be required for recurrent disease. |
| Databáze: | OpenAIRE |
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