| Autor: |
V F, Chekhun, D M, Storchai, I N, Todor, T V, Borikun, N Yu, Lukianova |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Experimental oncology. 40(3) |
| ISSN: |
1812-9269 |
| Popis: |
To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF.The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF.Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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