| Autor: |
Hendriks, Michelle, Verhoeven, Virginie J M, Buitendijk, Gabriëlle H.S., Polling, Jan Roelof, Meester-Smoor, Magda A., Hofman, Albert, van Huet, Ramon A C, Klevering, B Jeroen, Bax, Nathalie M., Lambertus, Stanley, Klaver, Caroline C W, Hoyng, Carel B., Oomen, Clasien J, van Zelst-Stams, Wendy A. G., Cremers, Frans Pm, Plomp, Astrid S, van Schooneveld, Mary J., van Genderen, Mies M., Schuil, José, Boonstra, F Nienke, Schlingemann, Reinier O, Bergen, Arthur A., Pierrache, Laurence, Meester-Smoor, Magda, van den Born, L Ingeborgh, Boon, Camiel J.F., Pott, Jan W.R., van Leeuwen, Redmer, Kroes, Hester Y., de Jong-Hesse, Yvonne, Kamermans, Maarten, Ingeborgh van den Born, L., RD5000 Consortium |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Purpose It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene, and refractive error in IRDs may provide insight herein. Design Case-control study. Methods STUDY POPULATION: Total of 302 patients with IRD from 2 ophthalmogenetic centers in the Netherlands. REFERENCE POPULATION: Population-based Rotterdam Study-III and Erasmus Rucphen Family Study (N = 5550). Distributions and mean spherical equivalent (SE) were calculated for main affected cell type and causal gene; and risks of myopia and hyperopia were evaluated using logistic regression. Results Bipolar cell-related dystrophies were associated with the highest risk of SE high myopia 239.7; odds ratio (OR) mild hyperopia 263.2, both P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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