| Autor: |
Demirbas, Orhan, Basar, Figen, Atmaca, Sinan, Tekat, Atilla |
| Přispěvatelé: |
OMÜ |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
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| Popis: |
WOS: 000267954400011 Objective: We aimed to investigate the effects of early and late dexamethasone treatment combined with antibiotics on hearing preservation on experimental rat pnemococcal meningitis model. Materials and Methods: Thirty rats with confirmed diagnosis of meningitis after intracisternal S. pneumonia injection were randomly assigned to 3 groups. Animals in group 1 recieved intramuscular (im) ceftriaxone for 7 days, animals in group 2 recieved im dexamethasone on days 4-7 adjunct to im ceftriaxone treatment and animals in group 3 received im dexamethasone on days 1-4 adjunct to im ceftriaxone treatment. Hearing status of all rats were evaluated by auditory brainstem responses (ABR) on days 7 and 28 and categorized as normal hearing, moderate hearing loss, severe hearing loss and profound hearing loss. Results: Right ear ABR results on day 7 showed statistically significant difference in hearing levels among the groups favoring steroid treatment (p0.05). Right and left ear ABR results on day 28 showed statistically significant difference in hearing levels among the groups favoring steroid treatment (p0.05). Conclusions: Administration of dexamethasone, especially early in the course of the disease, concurrent with antibiotics will have otoprotective effects in individuals with pneumococcal meningitis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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