| Popis: |
The purpose of the present study was to monitor the time course of serum bone markers concentrations in experimental models of normally healing and complicated fractures of the canine femur. Twelve dogs were divided into two groups: group I (six dogs) with experimental normally healing (NH) fractures and group II (six dogs) with experimentally induced post fracture osteomyelitis of the femur (OM group). Clinical (heart rate, respiratory rate, body temperature) and radiological investigations were carried out over two months after the surgery. By the end of the 1st, 2nd, 3rd and 4th post operative weeks, blood was sampled for analysis of bone formation (total and bone alkaline phosphatase, osteocalcin) and bone resorption (carboxy-terminal telopeptide of type I collagen – ICTP) markers. In the NH group, serum ICTP concentrations were statistically significantly increased by the 1st and 2nd post operative weeks and then returned to normal levels. In the OM group, ICTP was increased considerably by the end of the second week but remained high until the end of the 2nd month. The initial increase occurred before the appearance of specific radiological signs. In the OM group, bone alkaline phosphatase and osteocalcin were also significantly higher, but rapidly declined to baseline concentrations. |
