Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats
| Autor: | Burdette, J. E., Liu, J., Lantvit, D., Lim, E., Booth, N., Bhat, K. P. L., Hedayat, S., Van Breemen, R. B., Constantinou, Andreas I., Pezzuto, J. M., Farnsworth, N. R., Bolton, J. L. |
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| Přispěvatelé: | Constantinou, Andreas I. [0000-0003-0365-1821] |
| Rok vydání: | 2002 |
| Předmět: |
isoflavone derivative
animal experiment Mammary gland cell stimulation animal tissue Rats Sprague-Dawley uterus weight Mammary Glands Animal estradiol Trifolium pratense Animals Animalia controlled study rat rat strain nonhuman Dose-Response Relationship Drug Plant Extracts animal model Uterus article food and beverages Estrogenic Estrogens Organ Size clover Fallopia Isoflavones unclassified drug estrogen activity Rats red clover extract female cell proliferation ovariectomy Vagina plant extract Trifolium hormones hormone substitutes and hormone antagonists Cell Division |
| Zdroj: | Journal of Nutrition J.Nutr. |
| Popis: | Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones was administered by gavage [250, 500 and 750 mg/(kg·d)] to virgin, ovariectomized 50-d-old Sprague-Dawley rats, for 21 d in the presence and absence of 17β-estradiol [50μg/(kg·d)]. Estrogenic effects included an increase in uterine weight, vaginal cell cornification and mammary gland duct branching. Red clover produced a dose-dependent increase in uterine weight and differentiated vaginal cells at the two higher doses, but it did not stimulate cell proliferation in the mammary glands. Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model. 132 27 30 Cited By :62 |
| Databáze: | OpenAIRE |
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