VALIDATION OF THE FRACTIONAL EXHALED BREATH TEMPERATURE MEASUREMENT AND ITS ASSOCIATION WITH DIFFERENT INTRINSIC, EXTRINSIC AND ENVIRONMENTAL FACTORS IN HEALTHY SUBJECTS

Autor: Huljev Šipoš, Ivana
Přispěvatelé: Labor, Marina, Vlahoviček, Kristian
Jazyk: chorvatština
Rok vydání: 2022
Předmět:
Popis: Temperatura izdahnutog zraka (EBT) poznata je kao biomarker upale i prokrvljenosti dišnih putova. U istraživanju je mjerena temperatura različitih frakcija izdahnutog zraka, fEBT (iz perifernih i centralnih dišnih putova). Svrha ovog istraživanja bila je validirati tu metodu kako bi se utvrdile referentne vrijednosti te utjecaj različitih čimbenika na njih. Hipoteze istraživanja bile su da je fEBT iz centralnog dišnog sustava niži i varijabilniji u odnosu na onaj iz periferne frakcije te da je statistički značajno povezan s tjelesnom temperaturom mjerenom na specifičnim točkama. Ova presječna studija obuhvaćala je 55 odraslih osoba kojima je opetovano mjeren fEBT, dva dana za redom, koristeći FractAir uređaj. Mjereni su i bazalni metabolizam, razina fizičke aktivnosti, udaljenost od glavne prometnice, vanjska i sobna temperatura, tlak i vlaga u zraku, KKS, CRP, plućne funkcije, kumulirani EBT i tjelesne temperature. Rezultati su osnovnu hipotezu potvrdili, dok je sekundarna odbačena. Također, pokazali su da fEBT nije povezan s tjelesnom temperaturom (p > 0,05 za sve) te da je ponovljiv tijekom dvaju uzastopnih dana. Svi su fEBT-ovi korelirali s temperaturom sobnog zraka (p < 0,01). U multivarijatnoj analizi nisu nađene povezanosti fEBT s ostalim osobnim i vanjskim čimbenicima. Pri temperaturi sobe od 22 °C fiziološke vrijednosti temperature prve frakcije bile su 23,481 ± 3,150 °C, druge frakcije 26,114 ± 4,024 °C, a treće frakcije 28,216 ± 3,321 °C. Exhaled air temperature (EBT) is known as a biomarker of inflammation and airway blood flow. The temperature of different fractions of exhaled air, fEBT (from peripheral and central airways) was measured in the research. The purpose of this study was to validate this method in order to determine the reference values and the influence of different factors on them. The research hypotheses were that fEBT from the central respiratory system was lower and more variable than the one from the peripheral and that it was statistically related to body temperature measured at specific points. This cross-sectional study included 55 adults in which the fEBT was repeatedly measured, two days in a row, using a FractAir device. Basal metabolism, level of physical activity, distance from the main road, outdoor and room temperature, air pressure and humidity, KKS, CRP, lung function, accumulated EBT and body temperatures were also measured. The results confirmed the primary hypothesis, while the secondary was rejected. They also showed that fEBT was not associated with body temperature (p> 0.05 for all) and was recurrent for two consecutive days. All fEBTs correlated with room temperature (p
Databáze: OpenAIRE