| Autor: |
Pastouret, Frederic, Cardozo, Lucia, Lamote, Jan, Lievens, Pierre |
| Přispěvatelé: |
Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physical Therapy, Surgical clinical sciences, Vriendenkring VUB, Rehabilitation Research, Surgery |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Popis: |
Introduction: It is difficult to create a chronic lymphoedema after Axillary Nodes Dissection (AND) without additional chemical inflammatory drugs or physical technique applications on animal models. However, according to other authors, “Lymphatic Fluid Stasis” (FLS) due to AND only seems to be the acute departure of the first tissue changes inducing a secondary lymphoedema on animal. Objective: The aim of this study is to appreciate the morphological effects of AND on the rat’s front leg and to detect FSL in the subcutaneous tissue and Functional Substitution Lymphatic Pathways (FSLP). Methods: Left superficial and deep AND was performed on 30 females Wistar rats with a new posterior surgical approach. Volume changes of two front legs were appreciated 12 weeks after surgery by pressure variation assessment of water displacement during legs immersion. Indocyanine Green mapping was performed to detect LFS and FSLP after skin dissection. Results: 43% of rats showed only a regeneration of interrupted lymphatic pathways. 27% showed only FSLP connected to the deep lymph vessels by perforating lymph vessels, while 30% of animals present the two phenomena. In all cases, FLS was not detected. Statistical difference (p=0.0350) of pressure variations (mmHg, mean±sd) between operated (0,4014 ± 0,05338) and non operated (0,4300±0,04513) sides was found. This result indicates there is not an increase of the operated front leg volume compare to the non operated leg. Conclusions: Contrary to the hypothesis submitted in the literature, rat’s AND does not necessarilly induce after 12 weeks a LFS considered as the first pathological event that leads to a secondary lymphoedema. Lymphatic pathways regeneration and FLSP, especially “perforating vessels” in the rat, seem to be the key to prevent LFS. This type of substitution pathways after AND on rat has never been described in the literature before. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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