| Autor: |
Giannitrapani L, Cervello M, Corsale S, Soresi M, Pipitone L, Montalto G, Vizzini G |
| Přispěvatelé: |
Giannitrapani L, Cervello M, Corsale S, Soresi M, Pipitone L, Montalto G, Vizzini G |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Introduction Liver transplantation (LT) for hepatocellular carcinoma (HCC) is a satisfactory therapeutic choice in patients with “early HCC” selected according to Milan criteria. However, the risk of HCC recurrence after LT is about 7-20% at five years and molecular markers which can predict recurrence are still lacking. We investigated in HCC samples and LC surrounding tissues the significance of VEGFR-2, HSP90, and GRP78/BiP expression in patients with HCC who underwent LT in a western transplantation center and their possible role as molecular markers of recurrence. Methods 42 patients (35 M, 7 F) with early HCC who underwent LT between 2012 and 2013 were enrolled. The tumor recurrence rate was analyzed after a minimum follow-up of 36 months. Immunohistochemical expression of VEGFR-2, HSP90, and GRP78/BiP in HCC tissues and LC surrounding tissues, was correlated with clinicopathological variables and recurrence-free post-LT survival. At statistical analysis t Student’s or Mann Whitney U test were used where appropriate. To assess which variable measured at baseline was predictive of HCC recurrence, the univariate Cox proportional hazards model (Hr) was fitted to each variable. All variables with a P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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