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Background and objective The 6‐min walk test (6MWT) is the most widely utilized method of assessing exercise capacity in pulmonary arterial hypertension (PAH). Cardiopulmonary exercise testing has the advantage of providing additional physiological information over 6MWT. The goals of our study were to describe the addition of gas exchange measurements to 6MWT and to determine how these parameters were related to the severity of PAH in three major subgroups of PAH (idiopathic (IPAH), connective tissue disease‐related (CTPAH) and congenital heart disease‐related (CHPAH)). Methods Seventy‐six PAH patients (IPAH, n = 28; CTPAH, n = 24; CHPAH, n = 24) completed the 6MWT with simultaneous gas exchange measurements. The 6‐min walk distance (6MWD), oxygen uptake (urn:x-wiley:resp:media:resp12868:resp12868-math-0001 O2 ), carbon dioxide production (urn:x-wiley:resp:media:resp12868:resp12868-math-0001 CO2 ), oxygen saturation, minute ventilation to carbon dioxide output (urn:x-wiley:resp:media:resp12868:resp12868-math-0001 E/urn:x-wiley:resp:media:resp12868:resp12868-math-0001 CO2 ) and end‐tidal partial pressure for carbon dioxide (PETCO2 ) were compared between subgroups, different functional classes (FCs) and pharmacotherapy. Results Whilst no significant difference in 6MWT was observed, absolute urn:x-wiley:resp:media:resp12868:resp12868-math-0001 O2 and urn:x-wiley:resp:media:resp12868:resp12868-math-0001 CO2 were higher for IPAH (P |
