Significance of IMP3, nucleophosmin, and Ki-67 expression in papillary thyroid carcinoma
| Autor: | Yorukoglu A, Yalcin N, Avci A, Cakalagaoglu F, Yaylali G, Akin F, Haciyanli M, Ozden A |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
integumentary system
Adolescent Adult Aged Aged 80 and over Biomarkers Tumor/*metabolism Carcinoma Papillary/*diagnosis/metabolism/pathology Cell Proliferation Diagnosis Differential Female Goiter Nodular/diagnosis/metabolism/pathology Humans Ki-67 Antigen/*metabolism Male Middle Aged Nuclear Proteins/*metabolism RNA-Binding Proteins/*metabolism Sensitivity and Specificity Thyroid Gland/metabolism/pathology Thyroid Neoplasms/*diagnosis/metabolism/pathology Thyroiditis/diagnosis/metabolism/pat |
| Popis: | The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism. |
| Databáze: | OpenAIRE |
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