Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population

Autor: Yalcintepe, Sinem, Ozdemir, Ozturk, Hacivelioglu, Servet Ozden, Akurut, Cisem, Koc, Evrim, Uludag, Ahmet, Cosar, Emine, Silan, Fatma
Přispěvatelé: [Yalcintepe, Sinem -- Ozdemir, Ozturk -- Akurut, Cisem -- Uludag, Ahmet -- Silan, Fatma] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Genet, Canakkale, Turkey -- [Yalcintepe, Sinem] Numune Training & Educ Hosp, Genet Diag Ctr, Adana, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Hacivelioglu, Servet Ozden -- Koc, Evrim -- Cosar, Emine] Canakkale Onsekiz Mart Univ, Sch Med, Dept Gynecol & Obstet, Canakkale, Turkey
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Popis: WOS: 000363549000006
PubMed ID: 26261801
The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with >= 1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic polymorphism, but the rest of the patients and fetal materials had combined thrombophilic polymorphisms. The PAI-1 4G/5G+4G/4G (P=0.0017), 4G/4G (P=0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for spontaneous abortions and results need to be confirmed by larger sample size.
Scientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP) [2012-029]; ethics committee of COMU
This project was funded by Scientific Research Projects fund of Canakkale Onsekiz Mart University (COMU-BAP, 2012-029) and supported by the ethics committee of COMU.
Databáze: OpenAIRE
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