Effect of subgingival syringe and passive ultrasonic irrigation on IL-1β, IL-6 AND TNF-α levels in experimental periodontitis in rats
| Autor: | MOUCHREK, Monique Maria Melo |
|---|---|
| Přispěvatelé: | SILVA, Vanessa Camila da, BENATTI, Bruno Braga, NUNES, Lívia Helena de Araújo Castro |
| Jazyk: | portugalština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UFMA Universidade Federal do Maranhão (UFMA) instacron:UFMA |
| Popis: | Submitted by Daniella Santos (daniella.santos@ufma.br) on 2022-08-23T12:05:22Z No. of bitstreams: 1 MONIQUEMOUCHREK.pdf: 1535383 bytes, checksum: 9936c361c9476f6842da18919373ecf6 (MD5) Made available in DSpace on 2022-08-23T12:05:22Z (GMT). No. of bitstreams: 1 MONIQUEMOUCHREK.pdf: 1535383 bytes, checksum: 9936c361c9476f6842da18919373ecf6 (MD5) Previous issue date: 2015-02-19 Background: The persistence of sites with periodontal disease after treatment with scaling and root planing, which is considered the standard nonsurgical gold treatment in periodontics, triggered the series of studies in the search for an operative treatment for these situations. In Endodontics, irrigation with syringe has been associated with passive ultrasonic irrigation presenting thorough cleaning and antimicrobial efficacy. Whereas the benefit found in endodontic area with the use of this technique, we sought to adapt the ultrasonic irrigation for subgingival use. Thus, the aim of this study was to evaluate the subgingival irrigation with syringe (IS) and / or passive ultrasonic subgingival irrigation (ISUP) with saline (SF), sodium hypochlorite (HS) and propolis extract (PRO) influences the concentration of the inflammatory mediators IL-1β, IL-6 and TNF-α-induced periodontitis in an experimental rat. Methods: Experimental periodontitis was induced by placement of the bandage in the first molars of 35 Wistar rats. After 14 days, the bandages were removed, and the animals previously scaled, followed by IS in the left hemi-mandible and ISUP in direira, with SF 0.9%, 0.1% and HS PRO 11%. The animals were sacrificed 2 days after treatment and subjected to ELISA to evaluate the levels of cytokines IL-1β, IL-6 and TNF-α. The data were analyzed by the statistical program SPSS Statistics 20 (2011) and the significance level (α) was 5%, that is, were considered significant when p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|