Allele frequency of HLA-DRB1 in brasilian patients with rheumatoid arthritis
| Autor: | Usnayo, Magali Justina Gómez |
|---|---|
| Přispěvatelé: | Pinheiro, Geraldo da Rocha Castelar, Pôrto, Luís Cristóvão de Moraes Sobrino, Levy, Roger Abramino, Salgado, Maria Cecília da Fonseca, Carneiro, Sueli Coelho da Silva, Bica, Blanca Elena Rios Gomes, Klumb, Evandro Mendes |
| Jazyk: | portugalština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T19:41:25Z No. of bitstreams: 1 Magali Justina Gomez Usnayo Dissertacao completa.pdf: 2363013 bytes, checksum: 662eed7c9d251e17761ebd076e101ff9 (MD5) Made available in DSpace on 2021-01-05T19:41:25Z (GMT). No. of bitstreams: 1 Magali Justina Gomez Usnayo Dissertacao completa.pdf: 2363013 bytes, checksum: 662eed7c9d251e17761ebd076e101ff9 (MD5) Previous issue date: 2011-07-18 HLA-DRB1 alleles that encode an amino acid sequence at positions 70-74 of the third hypervariable region of the B chain of the DRB1 gene, called shared epitope (SE), are associated with increased susceptibility and severity to rheumatoid arthritis (RA) in different populations. A new classification proposed by Du Montcel et al has been developed to determine the association between HLA-DRB1 and RA. This study was designer to determine the frequency of HLA-DRB1 alleles in Brazilian patients with RA, and its association with rheumatoid factor (RF), citrullinated peptide antibodies (ACPA) and radiographic joint damage and bone. Four hundred and twelve patients with RA and 215 controls were included. The HLA-DRB1 typing was performed by polymerase chain reaction (PCR) using specific primers and hybridization with sequence specific oligonucleotides (SSOP). The survey of ACPA was determined by ELISA and the RF by nephelometry, the radiographic evaluation by index method modified Sharp Van Der Heijde. For statistical analysis we used the chi-square, Student and logistic regression. In patients with rheumatoid arthritis HLA-DRB1*04:01, *04:04, *04:05 are associated with RA (p |
| Databáze: | OpenAIRE |
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