Genetic polymorphism of cytokines in the population Rio de Janeiro

Autor:	Silva, Gustavo Milson Fabricio da
Přispěvatelé:	Pôrto, Luís Cristóvão de Moraes Sobrino, Moraes, Milton Ozório, Hatagima, Ana
Jazyk:	portugalština
Rok vydání:	2009
Předmět:	CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA [CNPQ] Ethnicity Polymorphism (Genetics) Cytokines Polimorfismo de um único nucleotídeo Polimorfismo (Genética) Citocinas População - Aspectos genéticos Population - Genetic aspects Etnia Single nucleotide polymorphism
Zdroj:	Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ
Popis:	Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T18:13:09Z No. of bitstreams: 1 Gustavo Milson Fabricio da Silva Dissertacao completa.pdf: 3226786 bytes, checksum: 55f24bffeef4cff365f098957ac9ec18 (MD5) Made available in DSpace on 2021-01-05T18:13:09Z (GMT). No. of bitstreams: 1 Gustavo Milson Fabricio da Silva Dissertacao completa.pdf: 3226786 bytes, checksum: 55f24bffeef4cff365f098957ac9ec18 (MD5) Previous issue date: 2009-03-19 Cytokines are molecules that control and modulate the activities of numerous target cells via binding to specific receptors. The observed differences in the cytokine production among individuals can be, at least, explained by genetic polymorphisms like single nucleotide polymorphism (SNP). In 181 unrelated healthy Brazilian individuals from Rio de Janeiro City, we investigated the polymorphisms of cytokine genes encoding Tumor Necrosis Factor-alpha (TNFA), Transforming Growth Factor beta (TGFB), Interleukin (IL)-10, IL-6, and Interferon-gamma (IFNG). Polymerase chain reaction using sequence-specific primers genotyping was performed for these gene cytokines using the avaiable comercial kit CytGen (One Lambda Inc., CA, USA). Eight polymorphisms were tested: TNF-a (-308G/A); TGF-b (códon 10C/T, códon 25C/G); IL-10 (-1082A/G, -819T/C, -592A/C); IL-6 (-174G/C) and IFN-g (+874T/A). Chi-square test was used for comparisons. Observed data were compared to three other populations from different regions of Brazil (São Paulo, Paraná and Bahia) and three populations of other countries (Italy, Slovakia and North American Blacks). Our analysis from Rio de Janeiro population showed that the alleles frequencies in IL-10, IL-6 and IFN-g are unevenly distributed among Whites, Blacks and Mulatos (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3056::d1ad6612f57ac25cab686696a98c0c51 http://www.bdtd.uerj.br/handle/1/7830 Zobrazit plný text záznamu