Estudo do metabolismo renal da guanilina e das interações entre guanilina e uroguanilina com os peptideos natriureticos ANP e urodilatina
| Autor: | Santos Neto, Messias Simões dos |
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| Přispěvatelé: | Fonteles, Manasses Claudino |
| Jazyk: | portugalština |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Guanylin and uroguanylin share natriuretic and kaliuretic activities. While guanylin is inactivated by chymotrypsin ''in vitro'', uroguanylin resists to chymotrypsin attack. Experiments were done in the perfused rat kidney with chymostatin (a protease inhibitor - 600 µg/ml) to search for a possible renal metabolism of guanylin. E.coli heat-stable enterotoxin (STa), guanylin and uroguanylin also bind to and activate membrane guanylate-cyclase C (GC-C) expressed in the kidney and intestine. Atrial natriuretic peptide (ANP) and its renal form (urodilatin, UROD) have well known natriuretic effects and activate guanylate-cyclase A (GC-A). It is also our purposal to search for possible synergisms between ANP, UROD, guanylin and uroguanylin. At the dose used, chymostatin lacks effect in electrolyte reabsorptions. When introduced after chymostatin, guanylin lowered %TNa+ (from 81.3±1.9 to 72.7±2.45, p |
| Databáze: | OpenAIRE |
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