In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans

Autor: Forcin, Leticia Vendrametto, de Freitas, Rafaela Pignatti, Midena, Raquel Zanin, Weckwerth, Ana Carolina Villas Bôas, da Silva, Guilherme Ferreira [UNESP], Weckwerth, Paulo Henrique [UNESP]
Přispěvatelé: Centro de Ciencias da Saude, Pro Reitoria de Pesquisa e Pos Graduacao, Universidade do Sagrado Coracao, Universidade de São Paulo (USP), Pesquisador Cientifico da Secretaria da Saude do Estado de Sao Paulo, Universidade Estadual Paulista (UNESP)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-04-28T19:48:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Introduction: the frequency of invasive mycoses caused by opportunistic fungal pathogens has increased significantly in the last decades. Among the main etiological agents of opportunistic mycoses is Candida albicans. This yeast has several important virulence factors for producing disease. Some studies have demonstrated that C. albicans colonized root canals and dentinal tubules. The spectrum of antimicrobial activity of calcium hydroxide dressing should include this yeast. Objectives: the aim of the present study was to determine the in vitro susceptibility of four C. albicans strains collected from the oral cavity and a standard strain ATCC 10231 to calcium hydroxide paste associated with antifungal, antibiotic and anti-inflammatory drugs. The efficiency of the Ca(OH)2 paste associated with the drugs on the yeasts was analyzed by the radial diffusion method and also by the direct contact method. Data were analyzed by Kruskal Wallis test and the Dunn post-test were used to indicate the differences between the groups with a significance level of 5%. Results: all antifungal drugs increased the action of the calcium hydroxide pastes against Candida albicans. Conclusions: the association of antifungals with Ca(OH)2 may be considered for use as intracanal medicaments Universidade do Sagrado Coracao Centro de Ciencias da Saude Universidade do Sagrado Coracao Pro Reitoria de Pesquisa e Pos Graduacao Master’s degree in Oral Biology Universidade do Sagrado Coracao Doctorate degree in Applied Dental Sciences Endodontics area Universidade de Sao Paulo Faculdade de Odontologia de Bauru Instituto Lauro de Souza Lima Pesquisador Cientifico da Secretaria da Saude do Estado de Sao Paulo Specialist in Clinical Analysis Universidade do Sagrado Coracao Doctorate degree in Dentistry Universidade Estadual Paulista Faculdade de Odontologia de Araraquara Doctorate degree in Tropical Diseases Universidade Estadual Paulista Doctorate degree in Dentistry Universidade Estadual Paulista Faculdade de Odontologia de Araraquara Doctorate degree in Tropical Diseases Universidade Estadual Paulista
Databáze: OpenAIRE
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