Quantifying analysis of advanced glycosylation end products (AGEs) expression in periodontitis patients with diabetes type II
| Autor: | GRIMM WOLF-DIETER, SHCHETININ EVGENY VYACHESLAVOVICH, BOBRISHEV DMITRY VICTOROVICH, SIRAK SERGEY VLADIMIROVICH |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Медицинский вестник Северного Кавказа. |
| ISSN: | 2073-8145 2073-8137 |
| Popis: | Diabetes is an established risk factor for periodontitis. We investigated AGEs distribution in human gingival tissues and monocyte cytokine expression in diabetic patients with chronic periodontitis (DII/ cP). Within indicated surgical procedures gingival biopsies were taken from 10 DII/cP and from 10 healthy controls. Tissue samples were prepared for immunohistochemistry using a monoclonal antibody specific for AGEs (6D12, TransGenic Inc.) and IMAGES J was used for quantification. Mean clinical parameters in DII/cP presented typical for severe chronic periodontitis (mt: 10.5; BoP: 84%; PBI: 2.9; cAL: 5.5 mm; rAL: 6.9 mm). In gingival tissue from DII/cP immunohistochemistry showed enhanced accumulation of AGEs (17%) compared to controls (13%). This study found that diabetes and periodontitis results in further AGE-accumulation compared to periodontitis alone. These results suggest the possibility that the blockade of RAGE may provide an effective approach in a range of diabetic complications including periodontal disease. |
| Databáze: | OpenAIRE |
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