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PopovychIgor L.,GozhenkoAnatoliy I., Kuchma Igor L., Zukow Walery, Bilas Volodymyra R.,Koval’chuk Galyna Y., IvasivkaAnzhela S.Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats.Journal of Education, Health and Sport. 2020;10(11):320-336. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.11.033 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.11.033 https://zenodo.org/record/4582667 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.10.2020. Revised: 30.10.2020. Accepted: 30.11.2020. IMMUNOTROPIC EFFECTS OF SO-CALLED SLAG METABOLITES (CREATININE, UREA, URIC ACID AND BILIRUBIN) AT RATS Igor L. Popovych1,3, Anatoliy I. Gozhenko1, Igor L. Kuchma1, Walery Zukow2, Volodymyra R. Bilas3,Galyna Y. Koval’chuk4, Anzhela S. Ivasivka4 1Ukrainian Scientific Research Institute for Medicine of Transport, Odesa, Ukraine prof.gozhenko@gmail.com;igorkuchma@ukr.net 2Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl 3Bohomolets’ OO Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine i.popovych@biph.kiev.ua 4Ivan Franko Pedagogical University, Drohobych, Ukraine galynakovalchuk5@gmail.com Abstract Background. The study of the effect of end products of protein and nucleic acid metabolism on the immune system is of interest not only theoretical but also practical in line with the problems of urotoxins and hemodialysis.In previous studies, we found significant links between uricemia and uricosuria, on the one hand, and immune parameters, on the other hand.In this study, the spectrum of nitrogenous metabolites was expanded due to creatinine, urea and bilirubin. Material and methods. Experiment was performed on 60healthy female Wistar rats. The plasma level and urinary excretion of the nitrogenous metabolites were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as phagocytosis of blood neutrophils and monocytes.Results. Both negative and positive metabolic-immune correlations were revealed.Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of immune parameters revealed the maximum immunotropic effect of uricosuria(R=0,637).This is followed by excretion of urea (R=0,617) and creatinine (R=0,606), bilirubinemia (R=0,589), creatinineemia (R=0,567), uricemia (R=0,566) and plasma urea level (R=0,500). The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the parameters of immunity, on the other hand, was very strong: R=0,921; χ2(154)=282; p-6. Conclusion. Nitrogen metabolites exhibit significant immunotropic activity, both suppressor and enhancing. Keywords: uric acid,creatinine, urea, bilirubin, immunity, relationships, rats. |
