| Autor: |
Bridel, Sébastien, Watts, Stephen W., Judd, Louise M., Harshegyi, Taylor, Passet, Virginie, Rodrigues, Carla, Holt, Kathryn E., Brisse, Sylvain |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Popis: |
MotivationKlebsiellaspecies are increasingly multidrug resistant pathogens affecting human and animal health and are widely distributed in the environment. Among these, theKlebsiella pneumoniaespecies complex (KpSC), which includes seven phylogroups, is an important cause of community and hospital infections. In addition, theKlebsiella oxytocaspecies complex (KoSC) also causes hospital infections and antibiotic-associated haemorrhagic colitis. The unsuitability of widely used clinical microbiology methods to distinguish species within each of these species complexes leads to high rates of misidentifications that are masking the true clinical significance and potential epidemiological specificities of individual species.ResultsWe developed a web-based tool,KlebsiellaMALDI TypeR, a platform-independent and user-friendly application that enables uploading raw data from MALDI-TOF mass spectrometer to identifyKlebsiellaisolates at the species complex and phylogroup levels. The tool is based on a database of previously identified biomarkers that are specific for either the species complex, individual phylogroups, or related phylogroups, and is available athttps://maldityper.pasteur.fr. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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