| Autor: |
Q. Bernard, A.A. Smith, X. Yang, J. Koci, S.D. Foor, S.D. Kramer, X. Zhuang, J.E. Dwyer, Y.P. Lin, E.F. Mongodin, A. Marques, J.M. Leong, J. Anguita, U. Pal |
| Rok vydání: |
2018 |
| Popis: |
Borrelia burgdorferi is one of the few extracellular pathogens capableof establishing persistent infection in mammals. The mechanismsthat sustain long-term survival of this bacterium are largelyunknown. Here we report a unique innate immune evasion strategyof B. burgdorferi, orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants.BBA57 function is critical for early infection but largely redundantfor later stages of spirochetal persistence, either in mammalsor in ticks. The protein influences host IFN responses as well as suppressesmultiple host microbicidal activities involving serum complement,neutrophils, and antimicrobial peptides. We also discovered aremarkable plasticity in BBA57-mediated spirochete immune evasionstrategy because its loss, although resulting in near clearance of pathogensat the inoculum site, triggers nonheritable adaptive changesthat exclude detectable nucleotide alterations in the genome but incorporatetranscriptional reprograming events. Understanding themalleability in spirochetal immune evasion mechanisms that ensurestheir host persistence is critical for the development of novel therapeuticand preventive approaches to combat long-term infections likeLyme borreliosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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