Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases
| Autor: | López-Pedrera, Chary, Villalba, José Manuel, Patiño-Trives, Alejandra Mª, Luque-Tévar, Maria, Barbarroja, Nuria, Aguirre, Mª Ángeles, Escudero-Contreras, Alejandro, Pérez-Sánchez, Carlos |
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| Přispěvatelé: | [López-Pedrera,C, Patiño-Trives,AM, Luque-Tévar,M, Barbarroja,N, Aguirre,MA, Escudero-Contreras,A] Rheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain, [Villalba,JM, Pérez-Sánchez,C] Department of Cell Biology, Immunology and Physiology, Agrifood Campus of International Excellence, University of Córdoba, ceiA3, Córdoba, Spain, This study was supported by grants from the Instituto de Salud Carlos III (ref. PI18/00837), cofinanciado por el Fondo Europeo de Desarrollo Regional de la Unión Europea ‘Una manera de hacer Europa’, Spain, the Spanish Inflammatory and Rheumatic Diseases Network (RIER), Instituto de Salud Carlos III (RD16/0012/0015) and the Servicio Andaluz de Salud (PI-0285-2017), the Spanish Ministerio de Ciencia, Innovación y Universidades (MICIU) grant RTI2018-100695-B-I00, Junta de Andalucía grants P18-RT-4264, 1263735-R and BIO-276, the FEDER Funding Program from the European Union, and Universidad de Córdoba. C.L-P was supported by a contract from the Spanish Junta de Andalucia (‘Nicolas Monardes’ program). C.P.-S. was supported by a contract from the MICIU (‘Juan de la Cierva’ program). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Solubility [Medical Subject Headings]
Síndrome antifosfolípido Enfermedades autoinmunes del sistema nervioso Artritis reumatoide Chemicals and Drugs::Lipids::Lipoproteins [Medical Subject Headings] Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] Phenomena and Processes::Metabolic Phenomena::Pharmacokinetics::Biological Availability [Medical Subject Headings] Multiple sclerosis Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical [Medical Subject Headings] Systemic lupus erythematosus Antiphospholipid syndrome Lupus eritematoso sistémico Organisms::Eukaryota::Animals [Medical Subject Headings] Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 1 [Medical Subject Headings] Rheumatoid arthritis Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings] Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria [Medical Subject Headings] Inflammation Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings] Inflamación Estrés oxidativo Autoimmune disorders Diseases::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Lupus Erythematosus Systemic [Medical Subject Headings] Anatomy::Hemic and Immune Systems::Immune System::Leukocytes [Medical Subject Headings] Cardiovascular disease Phenomena and Processes::Physical Phenomena::Elementary Particles::Electrons [Medical Subject Headings] Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis Rheumatoid [Medical Subject Headings] Oxidative stress Esclerosis múltiple Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] Coenzyme Q10 Enfermedades cardiovasculares Diseases::Immune System Diseases::Autoimmune Diseases::Antiphospholipid Syndrome [Medical Subject Headings] Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases CNS::Multiple Sclerosis [Medical Subject Headings] |
| Popis: | Coenzyme Q10 (CoQ10) is a mitochondrial electron carrier and a powerful lipophilic antioxidant located in membranes and plasma lipoproteins. CoQ10 is endogenously synthesized and obtained from the diet, which has raised interest in its therapeutic potential against pathologies related to mitochondrial dysfunction and enhanced oxidative stress. Novel formulations of solubilized CoQ10 and the stabilization of reduced CoQ10 (ubiquinol) have improved its bioavailability and efficacy. Synthetic analogues with increased solubility, such as idebenone, or accumulated selectively in mitochondria, such as MitoQ, have also demonstrated promising properties. CoQ10 has shown beneficial effects in autoimmune diseases. Leukocytes from antiphospholipid syndrome (APS) patients exhibit an oxidative perturbation closely related to the prothrombotic status. In vivo ubiquinol supplementation in APS modulated the overexpression of inflammatory and thrombotic risk-markers. Mitochondrial abnormalities also contribute to immune dysregulation and organ damage in systemic lupus erythematosus (SLE). Idebenone and MitoQ improved clinical and immunological features of lupus-like disease in mice. Clinical trials and experimental models have further demonstrated a therapeutic role for CoQ10 in Rheumatoid Arthritis, multiple sclerosis and type 1 diabetes. This review summarizes the effects of CoQ10 and its analogs in modulating processes involved in autoimmune disorders, highlighting the potential of these therapeutic approaches for patients with immune-mediated diseases. Yes |
| Databáze: | OpenAIRE |
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