Recovery of rate-pressure product and cardiac mortality in coronary artery disease patients with type 2 diabetes

Autor: Kiviniemi, A. M. (Antti M.), Kenttä, T. V. (Tuomas V.), Lepojärvi, S. (Samuli), Perkiömäki, J. S. (Juha S.), Piira, O.-P. (Olli-Pekka), Ukkola, O. (Olavi), Huikuri, H. V. (Heikki V.), Junttila, M. J. (M. Juhani), Tulppo, M. P. (Mikko P.)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Popis: Aims: To investigate prognostic significance of post-exercise recovery of rate-pressure product (RPP) in patients with stable coronary artery disease (CAD) and type 2 diabetes (T2D). Methods: Patients with angiographically documented CAD and T2D (n = 697) underwent symptom-limited bicycle exercise test. Exercise capacity (EC), heart rate, blood pressure and RPP responses to peak exercise and recovery (2′ and 5′ after cessation of exercise) were analyzed. Cardiac death was the primary and sudden cardiac death (SCD) secondary endpoint. Results: During a median follow-up of 76 months, 49 cardiac deaths (7.0%) and 28 SCDs (4.0%) were observed. The recovery of RPP at 5′ was the strongest univariate predictor of cardiac death (hazard ratio [HR]: 2.55 per SD decrease, 95%CI: 1.82–3.58, p
Databáze: OpenAIRE