| Autor: |
Viazis, N. Giakoumis, M. Bamias, G. Goukos, D. Koukouratos, T. Katopodi, K. Karatzas, P. Triantos, C. Tsolias, C. Theocharis, G. Daikos, G.L. Ladas, S.D. Karamanolis, D.G. Mantzaris, G.J. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Popis: |
Aim To identify factors predicting mucosal healing in ulcerative colitis patients treated with anti-TNFα agents with or without azathioprine. Methods In a prospective, multicenter, one-year study biologic naïve patients aged 25–65 years, with corticosteroid-dependent or refractory colitis received combination treatment with anti-TNFα and azathioprine for 6 months followed by anti-TNFα monotherapy. Patients who denied combination therapy or were outside this age range received anti-TNFα monotherapy (controls). Before and at weeks 12 and 54 of treatment the total Mayo score was calculated. Mucosal healing was defined as endoscopic subscore of 0. Mucosal expression of T helper (Th) cell-lineage specific transcription factors (Tbet, Gata3, Rorc, FoxP3) before treatment was also associated with mucosal healing. Results Of 67 patients, 58 (86.6%) received combination and 9 (13.4%) anti-TNFα monotherapy. Overall 29 (43.3%) patients achieved mucosal healing; rates were higher in patients receiving combination therapy vs. monotherapy (p = 0.03) and in azathioprine naïve vs. exposed patients in the combination group (p = 0.01). Mucosal healing was associated with lower pre-treatment mucosal expression of transcription factor Th1–Tbet (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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