| Autor: |
Sandilos, Panagiotis Tatsis, Elias Vlachos, Lampros and Dardoufas, Constantinos Karaiskos, Pantelis Georgiou, Evangelos and Baras, Panagiotis Kipouros, Panagiotis Torrens, Michael and Angelopoulos, Angelos |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Popis: |
The polymer gel-magnetic resonance imaging (MRI) dosimetry technique was used to evaluate the mechanical and dose delivery accuracy in Leksell gammaknife stereotactic radiosurgery for the treatment of multiple targets. Two different polymer gel dosimeter formulations reported in the literature were prepared inhouse. A plan for the treatment of four brain metastases ( targets) was generated. It involved the delivery of four 8-mm collimator shots using different prescription isodose lines and different prescription doses for each target, keeping the maximum dose constant for all targets. A sample of each gel formulation was irradiated using a custom-made phantom with an experimental procedure capable of testing the increased nominal mechanical accuracy of stereotactic radiosurgery. The irradiated dosimeters were evaluated using a clinical 1.5 T MR imager. Result manipulation in 3D allowed for the determination of the mechanical accuracy in the delivery of each shot through the comparison of measured versus planned shot center coordinates. Dose delivery accuracy was also evaluated by comparison of maximum dose values measured at the center of each shot as well as dose distribution measurements, with corresponding treatment-planning calculations. Polymer gel dosimetry was found capable of verifying the complete chain of radiosurgery treatment in gamma-knife applications involving the irradiation of multiple targets. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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