| Autor: |
Lagopati, N. Kotsinas, A. Veroutis, D. Evangelou, K. Papaspyropoulos, A. Arfanis, M. Falaras, P. Kitsiou, P.V. Pateras, I. Bergonzini, A. Frisan, T. Kyriazis, S. Tsoukleris, D.S. Tsilibary, E.-P.C. Gazouli, M. Pavlatou, E.A. Gorgoulis, V.G. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Popis: |
Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2NPs) with anticancer potential. Materials and Methods: Ag/TiO2NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDAMB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO2NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions. © 2021 International Institute of Anticancer Research. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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