Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
| Autor: | Oliveira, Luciana S., Jesus, Liana I., Hechenleitner, Ana A. W., Albuquerque Cavalcanti, Osvaldo |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
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| Popis: | This work evaluated the influence of B-cyclodextrin (B-CD) on Eudragit® FS 30 D (FS) free film-forming capacity in the following blends: 90:10 and 95:5 (FS: B-CD) as material for potential application in colonic drug delivery systems. A control film (FS 100 %) was also prepared. Determination of swelling index (Is%) and permeability and physicochemical analysis were carried out. Formulations containing 95:5 or 90:10 FS: B-CD ratio and about 5 % of glyceryl monostearate (GMS) as a glidant provided homogeneous, continuous, and flexible films. Water vapour transmission (WVT) increased with an increase in B-CD concentration. On the other hand, how major was the B-CD amount lower was found the Is% for the film. Physicochemical analysis using TG revealed an initial thermal decomposition temperature shift that indicated lower thermal stability for films with 90:10 or 95:5 FS: B-CD ratio compared with the control (100:0). The results of FT-IR did not give evidence of any intermolecular interaction between B-CD and the acrylic polymer, showing just a physical mixture of both components in formulation. Colegio de Farmacéuticos de la Provincia de Buenos Aires |
| Databáze: | OpenAIRE |
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