Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity:Obesity and insulin injection depot kinetics

Autor:	Gradel, A. K. J., Porsgaard, Trine, Brockhoff, Per B., Seested, T., Lykkesfeldt, J., Refsgaard, H. H. F.
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Subcutaneous administration SDG 3 - Good Health and Well-being nutritional and metabolic diseases Injection depot Insulin absorption Obesity Insulin pharmacokinetics hormones hormone substitutes and hormone antagonists
Zdroj:	Gradel, A K J, Porsgaard, T, Brockhoff, P B, Seested, T, Lykkesfeldt, J & Refsgaard, H H F 2019, ' Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity : Obesity and insulin injection depot kinetics ', Obesity Science & Practice, vol. 5, no. 3, pp. 281-288 . https://doi.org/10.1002/osp4.326
DOI:	10.1002/osp4.326
Popis:	Objective:Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot structure and kinetics of the s.c. injection depot could contribute to this delay. Methods:Rats fed a high-fat diet (HFD) and low-fat diet (LFD) were included in a series of insulin pharmacokinetic and imaging studies. Injection depots were visualized with μCT imaging upon s.c. dosing with insulin aspart mixed with the contrast agent iomeprol, and insulin aspart exposure was measured by means of Luminescent Oxygen Channeling Immunoassay.Results:Body weight and fat mass was increased in rats fed a HFD vs. LFD (p
Databáze:	OpenAIRE
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