| Autor: |
Miguel, Verónica, Rey, Carlos, Aceña, José L., Maqueda, Francisco, Fernández-Hernando, Carlos, Rodríguez-Puyol, Diego, Vaquero, Juan J., Lamas, Santiago |
| Rok vydání: |
2020 |
| Předmět: |
|
| Popis: |
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression through post-transcriptional repression of their target messenger RNAs. A study of changes in expression of certain miRNAs in the kidney has supplied evidence on their pathogenic role and therapeutic potential in nephrology. This review proposes a nanotechnology approach based on the binding of analogs or inhibitors of miRNAs formed by peptide nucleic acids (PNAs) to peptides with a transmembrane structure sensitive to a low pH, called pHLIPs (pH [low] insertion peptides). The review draws on the concept that an acidic pH in the microenvironment of the renal tubule may facilitate concentration and distribution of the pHLIP-PNA complex in this organ. In this context, we have demonstrated for the first time that targeted administration of miR-33 inhibitors with the pHLIP system effectively prevents the development of renal fibrosis, thus opening up this technology to new strategies for diagnosis and treatment of kidney diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
