Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma; univariate and functionally-informed multivariate analyses
| Autor: | Vermeulen, R, Saberi Hosnijeh, F, Bodinier, B, Portengen, L, Liquet, B, Garrido Manriquez, J, Lokhorst, H, Bergdahl, I, Kyrtopoulos, S, Johansson, A-S, Georgiadis, P, Melin, B, Palli, D, Krogh, V, Panico, S, Sacerdote, C, Tumino, R, Vineis, P, Castagne, RS, Chadeau, M |
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| Přispěvatelé: | Cancer Research UK |
| Rok vydání: | 2018 |
| Předmět: |
mixed-effect modeling
Science & Technology BONE-MARROW prospective cohort FACTOR-ALPHA lymphoma multivariate models SERUM-LEVELS time to diagnosis OVARIAN-CANCER TRANSFORMING-GROWTH-FACTOR multiple myeloma CYTOKINE LEVELS EnviroGenoMarkers Consortium Consortium members Oncology POOR-PROGNOSIS cytokine INDEPENDENT PREDICTOR Oncology & Carcinogenesis NON-HODGKIN-LYMPHOMA Life Sciences & Biomedicine SOLUBLE CD30 1112 Oncology And Carcinogenesis |
| Popis: | Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case-control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years prior to diagnosis (range, 2.01-15.97) in 268 incident cases of BCL (including multiple myeloma) and matched controls. Linear mixed models, and Partial Least Square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes, and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed modelIrrespective of the model, our analyses identified associations linking blood lower immune markerslevels of and BCL incidence. In particular, we identified growth factors, and within that family, fibroblast growth factor-2 (FGF-2 , p=7.2x10 -4 ), ) and transforming growth factor alpha (TGF-α , p=6.5x10 -5 ) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF-2 (p=7.8x10 -7 ), TGF-α (p=4.08x10 -5 ), fractalkine (p=1.12x10 -3 ), monocyte chemotactic protein-3 (p=1.36x10 -4 ), macrophage inflammatory protein 1-alpha (p=4.6x10 -4 ), and vascular endothelial growth factor (p=4.23x10 -5 ). , and vascular endothelial growth factor (VEGF), to be consistently (and inversely) associated with MM incidence. Our results also provide d marginal support for already reported associations between chemokines and diffuse large B-Cell lymphoma (DLBCL) , and cytokines and chronic lymphocytic leukemia (CLL) . Case-only analyses showed that GM-CSF levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth-factors in the incidence of MM, and of chemokine and cytokine regulation in DLBCL and CLL. |
| Databáze: | OpenAIRE |
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